Medication for Gastroparesis

Unfortunately, medications to treat gastroparesis are limited. Most of them are used to treat symptoms and not the underlying disorder which limits effectiveness.

Aciphex- Used for GERD.

Ativan - used to control nausea, but causes extreme drowsiness.

Bethanechol - Used to stimulate esophageal motility.

Compazine- Used to control nausea, but can cause drowsiness, restlessness, etc.

Domperidone- Not FDA approved, but still available at compounding pharmacies in the US, or in other countries.   It may cause a prolonged QT interval on the EKG which can lead to sudden cardiac arrest, especially when used in conjunction with certain other medications.

Erythromycin- Often used for motility, but typically is not very effective especially if not taken with nausea meds. It may cause a prolonged QT interval on the EKG which can lead to sudden cardiac arrest, especially when used in conjunction with certain other medications.

Marinol- Approved Marijuana drug that is given to chemo patients or others with severe nausea. 

Nexium- Used for GERD as well as for healing an esophagus damaged by acid.

Periactin (cyproheptadine)- Used to relax the pyloric sphincter and as an appetite stimulant.

Promethazine- Used for nausea, but can cause drowsiness and restlessness.

Prevacid, Prilosec- Used for GERD .

Reglan- Used for nausea relief and to increase motility.  Unfortunately, it is not very well tolerated by many patients and currently has a black-box warning from the FDA.

Tricyclic Antidepressants (Elavil, nortriptyline, etc)- in small doses, these can help with nausea.  

Zofran- Used for nausea.