Colonic Inertia (also known as slow-transit constipation) is a motility disorder that affects the large intestine (colon) and results in the abnormal passage of stool. It is a rare condition in which the colon ceases to function normally.
In colonic inertia, stool may remain stored in portions of the colon and not progress adequately to the part of the colon (rectosigmoid) responsible for the propulsion and transfer of stool out of the body – the processes involved in defecation.
Colonic inertia is characterized by severe, unremitting constipation, abdominal distention, and abdominal pain. Individuals with colonic inertia often do not pass a stool for 7–10 days at a time and sometimes longer.
Sometimes colonic inertia is accompanied by abnormalities in motility of the upper intestine including delayed emptying of the stomach (gastroparesis) and small intestinal pseudo-obstruction (a disorder that causes symptoms of blockage, but no actual blockage).
Colonic inertia differs from regular constipation in that the latter patients have normal colonic transit times.