There are a limited number of medications available to patients with Gastroparesis.  Most medications are to treat symptoms rather than the underlying disorder.  

Aciphex- Used for GERD (www.aciphex.com)

Ativan - used to control nausea, but causes extreme drowsiness (http://www.medicinenet.com/lorazepam/article.htm)

Bethanechol - Used to stimulate esophageal motility (http://www.nature.com/ncpgasthep/journal/v4/n7/full/ncpgasthep0827.html)

Compazine- Used to control nausea, but can cause drowsiness, restlessness, etc. (http://www.healthsquare.com/newrx/com1097.htm)

Domperidone- Not FDA approved, but still available at compounding pharmacies in the US, or in other countries. It is covered by some insurance companies in the US. The current NDC# is 5197-3529-00. The ID number for the compound, which is used for insurance coverage, is #387791990-09.

Locate your nearest compounding pharmacy (or one of the ones listed below) and discuss the Domperidone compound # allowed in their system. Caremark prescription insurance will cover Domperidone. Please check to see if yours will too. You may call one US compounding pharmacy at 269-327-0033 and ask for their help. Be sure that you know your prescription insurance coding system. Insist that the phone representative let you speak with the appropriate person who has authority to approve your claim. The main side effects are lactation in women, but Domperidone rarely has serious side effects. (http://www.drugs.com/cons/Domperidone.html)

Other Compounding Pharmacies:
www.inhousepharmacy.com
or
www.millerspharmacy.com
1-888-891-3334

Erythromycin- Often used for motility, but typically is not very effective especially if taken with no other nausea meds. It may cause a prolonged QT interval on the EKG which can lead to sudden cardiac arrest, especially when used in conjunction with certain other medications. (http://www.medscape.com/viewarticle/448278, http://www.hanstenandhorn.com/hh-article12-04.pdf)

Marinol- Approved Marijuana drug that is given to chemo patients or others with severe nausea  (http://www.marinol.com/)

Nexium- Used for GERD as well as healing esophagus due to acid (www.purplepill.com)

Periactin (cyproheptadine)- Used to relax pyloric sphincter (couldn’t find this) and as appetite stimulant (http://www.merck.com/mmhe/sec09/ch119/ch119b.html)

Phenergan- Used for nausea, but can cause drowsiness and restlessness. (http://www.drugs.com/phenergan.html)

Prevacid- Used for GERD (www.prevacid.com)

Prilosec- Used for GERD  (www.prilosecotc.com)

Reglan- Used for nausea relief and to increase motility.  Unfortunately, it is not very well tolerated by many patients. (http://www.drugs.com/reglan.html)

Tricyclic Antidepressants (Elavil, nortriptyline, etc)- in small doses these help with nausea. (http://www.springerlink.com/content/u70164457476851v/

Zelnorm- Used for abdominal pain or discomfort, bloating, and constipation. Zelnorm was removed from the market in 2005 due to heart complications, but is available on a compassionate clearance basis to patients who require it. (www.zelnorm.com)

Zofran- Used in chemo patients for nausea. Not real impressive controlling GP related nausea, but works for a few patients (http://www.drugs.com/zofran.html)

 


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Page updated 11/2007